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NADH (Q1)
NADH, short for Nicotinamide-Adenine-Dinucleotide-Hydride, is also recognized as Coenzyme Q1, which is essential for energy production in each of the 100 trillion cells. It is the biologically active form of vitamin B3, also known as niacin (1). NADH is the biological form of hydrogen. It reacts with the oxygen present in every cell to form energy and water. The more NADH present in a cell, the more energy it produces, the better it functions and the longer it lives. NADH is present in all living cells such as human, animal and plant (2).
The cell, the most basic organizational unit of living organisms, contains an organelle specialized to provide energy for vital functions. Organelles called mitochondria are responsible for 95% of the energy produced in our body (3). This ability makes mitochondria an indispensable organelle for the cell. Mitochondria provide the energy required for all functions of the cell such as development, growth and reproduction (4). NADH assumes important functions in mitochondria, which function as the energy production center of cells (5).
Oxygen, glucose and NADH are needed for the production of body energy (6). Like lack of oxygen and glucose, lack of NADH leads to cell death. The energy level in cells decreases with advancing age. When it falls below a certain level, cells die and the body is more likely to develop many diseases (7).
A healthy body can produce as much NADH as it needs (9), but sometimes NADH levels may decrease in conditions such as chronic fatigue syndrome (8,14,16).
NADH is only taken in from outside through the food consumed. As we age, the need for NADH increases as its level in cells decreases. In addition to its critical role in energy production, it also has the function of triggering many important chemical reactions within the cell. More than 1,000 metabolic reactions are triggered and controlled by NADH.
NADH plays an important role in the production of neurotransmitters such as serotonin, dopamine and norepinephrine (10). Studies show that NADH regulates brain chemicals by accelerating the production of neurotransmitters such as norepinephrine, serotonin and dopamine (11).
What Does NADH Do? (9)
– Repairs damaged cells and DNA.
– It is a powerful antioxidant.
– It has the ability to stimulate adrenaline and dopamine.
– It increases the production of nitroxide, which is a neurotransmitter and has the most important effect on the relaxation of blood vessels.
– Increases ATP production from all mitochondria.
– Taking NADH supplements allows cells to generate more power and have more energy.
– Increases physical and mental endurance.
– Improves athletic performance.
– It increases cellular energy.
– Improves memory performance, concentration and attention.
– Regulates cholesterol and glucose levels.
– It helps in the fight against chronic fatigue, brain fog, burnout syndrome.
– In cases such as fatigue and depression, NADH intake may make the person feel energized (14,16).
– It protects and regenerates cells.
– It is effective in supporting the immune system and repairing DNA damages (2).
– Stimulates the production of neurotransmitters such as dopamine and norepinephrine. Increases libido in men and women.
– It is effective in the production of the hormone serotonin, which makes people feel happy.
– NADH supplements may reduce symptoms associated with Parkinson’s or Alzheimer’s disease (12).
Use synergy effects!
In nature, substances do not exist alone but in combination, as they complement each other and together produce a synergistic effect. It is therefore advisable to pay attention to a sensible combination when choosing a dietary supplement. In this way (14, 15, 16);
– It provides more energy to the cells.
– Improves physical performance.
– Improves mental performance and concentration.
– Relieves symptoms of jetlag.
– It positively supports the treatment of chronic fatigue syndrome.
– It has a positive effect on sexuality.
– It has a positive effect on the treatment of neurological degenerative diseases.
– It slows down the aging process.
– Not only does it have the ability to protect cells from damage, but it can also partially regenerate cells.
– It has a positive effect on blood pressure and cholesterol levels.
– It partially protects the body against harmful substances such as alcohol.
– It repairs DNA.
– It repairs the damage caused by insomnia.
– Strengthens the immune system.
– Regulates bone metabolism.
– Helps in the treatment of lipid metabolism disorders.
REFERENCES
- Poljsak B, & Milisav I. Vitamin B3 forms as precursors to NAD+: are they safe?. Trends in Food Science & Technology, 79, 198-203 (2018). https://doi.org/10.1016/j.tifs.2018.07.020
- Birkmayer GD. NADH, the Biological Hydrogen: The Secret of Our Life Energy. Basic Health Publications, Inc. (2009).
- Lane N. Mitochondrial disease: powerhouse of disease. Nature, 440(7084), 600-603 (2006).
- Xu X, Duan S, Yi F, Ocampo. Mitochondrial regulation in pluripotent stem cells. Cell metabolism, 18(3), 325-332 (2013).
- Kasimova MR, Grigiene J, Krab K. The free NADH concentration is kept constant in plant mitochondria under different metabolic conditions. The Plant Cell, 18 (3), 688-698 (2006).
- McKenna MC, Dienel GA, Sonnewald U. Energy metabolism of the brain. In Basic neurochemistry (pp. 200-231). Academic Press (2012).
- Xia W, Wang Z, Wang Q. Roles of NAD+/NADH and NADP+/NADPH in cell death. Current Pharmaceutical Design, 15(1), 12-19 (2009).
- Mikirova N, Casciari J, Hunninghake R. The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission. Altern Ther Health Med, 18(1), 36-40 (2012).
- Birkmayer G. (2010). Nadh.
- Hertoghe T. Lifting Depression With “Bio-identical” Mood Enhancers.
- Kelley C. NADH-Monograph Monograph (2006).
- Demarin V, Podobnik SS, Storga-Tomic D. Treatment of Alzheimer’s disease with stabilized oral nicotinamide adenine dinucleotide: a randomized, double-blind study. Drugs under experimental and clinical research, 30(1), 27-33 (2004).
- Nielsen L, & Ludvigsen, B. Improved method for determination of creatine kinase. The Journal of laboratory and clinical medicine, 62(1), 159-168 (1963).
- Marrero JC, Cordero MD, Segundo MJ. Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?. PMID: 25386668. DOI: 10.1089/ars.2014.6181
- Burke ER. NADH Energizes Mental and Physical Performance. From The January 98 issue of Nutrition Science News (2019).
- Jesús Castro-Marrero , Maria Jose Segundo, Marcos Lacasa. Effect of Dietary Coenzyme Q10 Plus NADH Supplementation on Fatigue Perception and Health-Related Quality of Life in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021 Jul 30;13(8):2658. doi: 10.3390/nu13082658.