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KLORELLA

It is a fact that living in the modern world can be harmful to your health. Everything from the air you breathe to the food you eat contains toxins that can harm your health.

It is possible to detoxify yourself from these toxins naturally. With chlorella, known as the “Superfood”, you can detoxify your body from heavy metals and other toxins while increasing your body’s energy levels thanks to the vital nutrients it contains.

What is Chlorella?

Chlorella originated from Greek and literally means “small fresh green”. It is a type of algae (microalgae) that is considered to have existed on earth for two million years and lives in fresh water. Thus, it is one of the oldest plants still living in the world. Historical illustrations show that Chlorella has been recognized since the 19th century. Chlorella, especially found on the island of Japan, is known to have many health benefits (1, 42).

Since chlorella has a tough cell wall that humans cannot digest, it must be taken as a supplement to reap its benefits. It is available in capsule, tablet, powder and extract form (2).

1. High nutrient content

Chlorella is considered to be an algae that will be integrated into our daily diet by 2030 (43). It has attracted the attention of many scientists due to its rich nutritional content. chlorella contains a very high amount of chlorophyll. Chlorophyll supports the liver in the detoxification process. It increases the oxygen carrying capacity of the blood. It also provides micronutrients needed by the body during chelation due to the high amount of vitamin A, beta carotene, iron, all B vitamins, vitamin C, calcium, folic acid, magnesium, zinc, copper, unsaturated fatty acids and trace amounts of iodine (43, 44, 45, 46). Many studies have shown that chlorella intake reduces oxidative stress (47, 48, 49). It has been proven to reduce serum lipid levels in hypercholesterolemic patients (50). It is known that chlorella stimulates the immune system, stimulates NK cells and triggers early inflammatory response (51). It has been proven that eicosopolysaccharides in the cell membrane bind heavy metals (52).

Chlorella is called a “superfood” because of its rich nutrient content. Its content varies depending on growing conditions, species and how the supplements are processed, but in particular it contains the following vital nutrients

  • Protein: 50-60% of chlorella is protein. It is a complete protein source because it contains all nine essential amino acids (2, 3).
  • Vitamin B12: Some varieties of chlorella may contain vitamin B12 (4).
  • Iron and vitamin C: Chlorella can be a good source of iron. Depending on the type of supplement you take, it can provide 6-40% of the daily requirement. It is also an excellent source of vitamin C, which helps improve iron absorption (1, 2).
  • Antioxidants Chlorella provides a wide range of antioxidants (1, 2).
  • Other vitamins and minerals: Chlorella contains small amounts of magnesium, zinc, copper, potassium, calcium, folic acid and other B vitamins (1, 2, 5).
  • Omega-3: Like other algae, chlorella also contains omega-3. Only 3 grams of chlorella provides 100 mg omega-3 (5).
  • Fiber: Contains low amounts of fiber. Chlorella can be a good source of fiber when taken in large amounts (1, 5).+

Nutrient Content in 3 g Chlorella (40)

2. Helps detox by binding heavy metals

This special seaweed preparation plays a fundamental role in heavy metal chelation. It mobilizes the heavy metals located in the connective tissue and causes their excretion by forming complexes with heavy metals in the intestines. Thus, while chronically mobilizing the metals in the connective tissue and putting them back into circulation, in the acute state, it prevents their absorption by forming chelates with heavy metals that are about to be absorbed from the intestines for various reasons (Permeable-bowel syndrome/Leaky Gut, high dose/intoxication…). Thus, it ensures that heavy metals are excreted through the intestines. Chlorella has the capacity to bind heavy metals such as mercury, cadmium, nickel, lead, palladium, platinum, gold, all metals used in dentistry and some environmental toxins (dioxin, formaldehyde, pesticides, etc.) like a sponge with high absorption power with its mucopolysaccharide cell membrane (53, 54, 55, 56).

Heavy metals such as Cd (Cd2+), Co, Cr (Cr3+, Cr6+, Cr2O7-2), Cu (Cu2+), Fe (Fe3+), Hg (Hg2+), Ni (Ni2+), Pb (Pb2+), Zn (Zn2+) are attracted and bound by chlorella like a sponge (57). Heavy metals in the connective tissue are removed from the connective tissue by chlorella and mobilized. Heavy metals are excreted via the enterohepatic circulation through the liver and into the intestine via bile. Chlorella binds only a part of the heavy metals that are free in the intestines, either through new food intake or enterohepatic excretion, without being reabsorbed from the intestines and causes them to be excreted. For this reason, Barlauch must be used simultaneously with chlorella to prevent the reabsorption of toxic metals from the intestines. When the studies with chlorella are examined, it is noticeable that almost all of them are made with the original chlorella grown on the Japanese island.

The chlorella to be used for chelation purposes must not have come into contact with any heavy metals, pesticides and chemicals in the place where it grows and during its growth. This means that it is very difficult to grow chlorella for chelation purposes and that special conditions must be met for this purpose. Because it will also bind heavy metals in the environment during its growth period, preparations made from chlorella produced under special and inappropriate conditions for chelation cannot bind heavy metals in the body, and may cause an increase in the toxicity table by releasing the heavy metals that it has bound during its growth in the body. This means that while aiming to provide chelation therapy, the heavy metal burden is aggravated and the condition worsens. This remarkable and direct determinant of the success of the treatment also applies to Barlauch, Koriander and Spiriluna mentioned in this article. For this reason, not all Chlorella, Barlauch, Koriander and Spiriluna in use are suitable for chelation purposes. Appropriate preparations should be selected for this purpose.

In summary, chlorella helps detoxify the body. Clinical studies show that it is effective in helping to remove heavy metals and other harmful compounds from the body (6, 7, 8).

Chlorella contains a unique phytonutrient called sporopollenin. Sporopollenin is more effective than other natural substances in binding neurotoxic residues. It has the ability to cleanse the body of biotoxins such as tuberculosis, lymes disease, tetanus toxins and mold. It also filters xenobiotics such as phytates, dioxins, pesticides and industrial wastes (41).

It binds heavy metals such as mercury, lead, nickel and aluminum and helps their excretion from the body. It can also detoxify food preservatives, artificial sweeteners and colorants from the body (41).

Although elements such as iron and copper fall into the heavy metal category, heavy metals such as cadmium and lead are more toxic. Although dangerous levels of heavy metal load in the body are rare, exposure to heavy metals may occur due to certain external factors such as environmental pollution (9).

Studies have found that algae, including chlorella, reduce heavy metal toxicity in the liver, brain and kidneys (10). In addition, chlorella has sometimes been shown to help reduce the amount of other harmful chemicals found in food (11).

Chlorella also increases the body’s production of glutathione, turning on the body’s natural detoxification switch. Glutathione is one of the body’s most powerful antioxidants, which functions to scavenge free radicals, replenish the antioxidant properties of vitamins C and E, and protect the body from damage while doing so (41).

From these studies, it has been found that chlorella may help boost the body’s natural ability to clear toxins.

3. It can strengthen your immune system

Your immune system helps you stay healthy by fighting infections. So far, studies have found that chlorella boosts immunity. In one study, male subjects produced more antibodies when taking chlorella supplements than when taking a placebo (12).

In another study, healthy adults taking chlorella were found to have increased immune activity (13).

4. May help lower cholesterol

Several studies have shown that chlorella supplements can help lower cholesterol (3, 14, 15). Specifically, some studies have shown that taking 5-10 grams of chlorella daily lowers total and LDL cholesterol and triglycerides in people with high blood pressure and/or mildly elevated cholesterol (3, 14).

The chlorella content may help improve blood lipid levels:

  • Niacin: Vitamin AB, known to lower cholesterol (1).
  • Fiber: A cholesterol-lowering substance (1, 16).
  • Carotenoids: A substance that naturally lowers cholesterol (14, 17, 18).
  • Antioxidants: Help prevent oxidation of LDL cholesterol, which is known to contribute to heart disease (19).

5. Shows antioxidant properties

Chlorella contains compounds considered antioxidants, including chlorophyll, vitamin C, beta-carotene, lycopene and lutein. These antioxidants can help fight many chronic diseases (20).

Some antioxidants contribute to the prevention of complications of diabetes (1, 21).

A clinical study showed that chlorella supplements increased antioxidant levels in smokers with a high risk of oxidative stress (22, 23).

6. Helps keep blood pressure under control

Chlorella supplements can help promote heart and kidney health, which are essential for normal blood pressure.

In one study, people with mild high blood pressure were given 4 grams of chlorella daily for 12 weeks. At the end of 12 weeks, these people had lower blood pressure values than those in the placebo group (24).

Another study in healthy men showed that taking chlorella supplements was associated with reduced levels of arterial stiffening, a factor that affects blood pressure (25).

7. Helps regulate blood sugar levels

Some research suggests that chlorella may help lower blood glucose levels (1).

The study showed that taking chlorella for 12 weeks reduced fasting blood glucose levels in both healthy individuals and individuals with a high risk of lifestyle-related diseases (15).

In another study, chlorella was shown to provide blood glucose control and improve insulin sensitivity in patients with non-alcoholic fatty liver disease (27, 28, 29).

8. May help manage respiratory diseases

Since chlorella contributes to the control of inflammation, it contributes to the reduction of symptoms of respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) (1, 30, 32).

9. May increase aerobic endurance

A study examined the effect of chlorella on aerobic endurance and observed positive effects. Researchers gave a group of young adults 4 grams of chlorella or a placebo 6 grams a day for 6 weeks.

At the end of the study, the chlorella group was able to fill their lungs with oxygen (a measure of endurance).

significantly improved, but there was no change in endurance in the placebo group (33).

Other Benefits of Chlorella

  • Supports eye health: Chlorella contains lutein and zeaxanthin, two carotenoids that protect the eye and reduce the risk of macular degeneration (34, 35, 36).
  • Supports liver health: Chlorella supplements have been shown to improve markers of liver health in people with liver disease. However, it is not clear whether there is a benefit for healthy people (27, 28, 29, 37).
  • Supports digestive functions: Many sources claim that chlorella facilitates digestion and reduces bloating.
  • Relieves premenstrual syndrome (PMS): Chlorella may alleviate premenstrual and menstrual symptoms thanks to the vital nutrients it contains (38, 39).

Treatment Duration and Dosage: The dose of chlorella used in chelation therapy is adjusted according to the heavy metal load of the person. It is recommended to take it with plenty of water before meals. Chlorella binds some of the heavy metals that are at risk of being taken with meals without being absorbed. Its main effect is to mobilize heavy metals that are both in circulation and precipitated in connective tissue, allowing them to pass through the liver into the intestine via bile. Depending on the severity of the heavy metal load, this dose can be increased. Since the purification process should be carried out without exhausting the system, chelation therapy should last at least 6 months (depending on the level of heavy metal burden, it may take 1 year or longer), starting with chlorella and continuing with the addition of other phytochelators after 2 weeks.

Side Effect

No serious side effects of chlorella supplementation have been observed (58). Chlorella treatment is considered to have no toxicity. It has been reported that very high doses (500 g/day) may cause intestinal gas formation (59).

Use in Special Populations and Cautions

Use in Pregnancy and Lactation: Chelation with chlorella is not normally recommended during pregnancy. Pregnant women should consult a physician before use. Studies have shown that the use of chlorella in pregnant women reduces dioxin passage through the umbilical cord (60). In lactating mothers, it was found that addition of chlorella decreased the amount of dioxin in breast milk and increased the amount of immunoglobulin A (61).

Use in Special Populations: Since chlorella contains low amounts of iodine, it may cause allergic reaction in people with iodine sensitivity. In people with autoimmune diseases such as multiple sclerosis, systemic lupus, etc., chlorella should be used with caution because it has immunostimulant effect (62). There is no harm in chlorella supplementation in patients with liver disease (hepatitis). It has been reported to decrease the serum level of alanine aminotransferase (ALT) (64).

Since vitamin C can destroy the chlorophyll in chlorella, it is not recommended to use products containing vitamin C together with chlorella during the chelation process.

REFERENCES

  1. Panahi Y, Darvishi B, Jowzi N. Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties. Curr Pharm Des. 2016;22(2):164-73. doi: 10.2174/1381612822666151112145226.
  2. Safi C, Zebib B, Merah O. Morphology, composition, production, processing and applications of Chlorella vulgaris: A review. Renewable and Sustainable Energy Reviews Volume 35, July 2014, Pages 265-278. https://doi.org/10.1016/j.rser.2014.04.007
  3. Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med. May-Jun 2001;7(3):79-91. PMID: 11347287
  4. Watanabe F, Yabuta Y, Bito T. Vitamin B₁₂-containing plant food sources for vegetarians. Nutrients 2014 May 5;6(5):1861-73. doi: 10.3390/nu6051861.
  5. PANAHI Y, PISHGOO B, JALALIAN HR. Investigation of the effects of Chlorella vulgaris as an adjunctive therapy for dyslipidemia: Results of a randomized open-label clinical trial.  Nutrition & Dietetics 2012. https://doi.org/10.1111/j.1747-0080.2011.01569.x
  6. Sears ME. Chelation: Harnessing and Enhancing Heavy Metal Detoxification-A Review. ScientificWorldJournal. 2013; 2013: 219840. doi: 10.1155/2013/219840
  7. Queiroz ML, Rodrigues AP, Bincoletto C. Protective effects of Chlorella vulgaris in lead-exposed mice infected with Listeria monocytogenes. Int Immunopharmacol 2003 Jun;3(6):889-900. doi: 10.1016/S1567-5769(03)00082-1.
  8. Uchikawa T, Kumamoto Y, Maruyama I. Enhanced elimination of tissue methylmercury in Parachlorella beijerinckii-fed mice. J Toxicol Sci 2011 Jan;36(1):121-6. doi: 10.2131/jts.36.121.
  9. Alissa EM, Ferns FA. Heavy Metal Poisoning and Cardiovascular Disease. J Toxicol. 2011; 2011: 870125. Published online 2011 Sep 8. doi: 10.1155/2011/870125
  10. Zhai Q, Narbad A, Chen W. Dietary Strategies for the Treatment of Cadmium and Lead Toxicity. Nutrients. 2015 Jan; 7(1): 552-571. doi: 10.3390/nu7010552
  11. Nakano S, Takekoshi H, Nakano M. Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk. J Med Food 2007 Mar;10(1):134-42. doi: 10.1089/jmf.2006.023.
  12. Otsuki T, Shimizu K, Lemitsu M. Salivary secretory immunoglobulin A secretion increases after 4-weeks ingestion of chlorella-derived multicomponent supplement in humans: a randomized cross over study. Nutr J 2011 Sep 9;10:91. doi: 10.1186/1475-2891-10-91.
  13. Kwak JH, Baek SH, Woo Y. Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial). Nutr J. 2012 Jul 31;11:53. doi: 10.1186/1475-2891-11-53.
  14. Ryu NH, Lim Y, Park JE. Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study. Nutr J. 2014 Jun 11;13:57.  doi: 10.1186/1475-2891-13-57.
  15. Mizoguchi T, Takehara I, Masuzawa T. Nutrigenomic studies of effects of Chlorella on subjects with high-risk factors for lifestyle-related disease. J Med Food. 2008 Sep;11(3):395-404. doi: 10.1089/jmf.2006.0180.
  16. Sano T, Kumamoto Y, Okuda M. Effect of lipophilic extract of Chlorella vulgaris on alimentary hyperlipidemia in cholesterol-fed rats. Artery. 1988;15(4):217-24. PMID: 3136759
  17. Ntanios FY, Duchateau GS. A healthy diet rich in carotenoids is effective in maintaining normal blood carotenoid levels during the daily use of plant sterol-enriched spreads. Int J Vitam Nutr Res. 2002 Jan;72(1):32-9. doi: 10.1024/0300-9831.72.1.32.
  18. Brady WE, Perlman JA, Bowen P. Human serum carotenoid concentrations are related to physiologic and lifestyle factors. J Nutr. 1996 Jan;126(1):129-37. doi: 10.1093/jn/126.1.129.
  19. Trpkovic A, Resanovic I, Stanimirovic J. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2015;52(2):70-85. doi: 10.3109/10408363.2014.992063. Epub 2014 Dec 24.
  20. Lordan S, Ross RP, Stanton C. Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases. Mar Drugs. 2011; 9(6): 1056-1100. Published online 2011 Jun 14. doi: 10.3390/md9061056
  21. Yamagishi S, Nakamura K, Inoue. Therapeutic potentials of unicellular green alga Chlorella in advanced glycation end product (AGE)-related disorders. Med Hypotheses. 2005;65(5):953-5. doi: 10.1016/j.mehy.2005.05.006.
  22. Panahi Y, Mostafazadeh B, Abrishami A. Investigation of the effects of Chlorella vulgaris supplementation on the modulation of oxidative stress in apparently healthy smokers. Clin Lab. 2013;59(5-6):579-87. doi: 10.7754/clin.lab.2012.120110.
  23. Ozguner F, Koyu A, Cesur G. Active smoking causes oxidative stress and decreases blood melatonin levels. Toxicol Ind Health. 2005 Mar;21(1-2):21-6. doi: 10.1191/0748233705th211oa.
  24. Shimada M, Hasegawa T, Nishimura C. Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. Clin Exp Hypertens. 2009 Jun;31(4):342-54. doi: 10.1080/10641960902977908.
  25. Otsuki T, Shimizu K, Iemitsu M. Multicomponent supplement containing Chlorella decreases arterial stiffness in healthy young men. J Clin Biochem Nutr. 2013 Nov;53(3):166-9. doi: 10.3164/jcbn.13-51. Epub 2013 Oct 3.
  26. Sansawa H, Takahashi M, Tsuchikura S. Effect of chlorella and its fractions on blood pressure, cerebral stroke lesions, and life-span in stroke-prone spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo). 2006 Dec;52(6):457-66. doi: 10.3177/jnsv.52.457.
  27. Mameghani ME, Sadeghi Z, Farhangi MA. Glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with non-alcoholic fatty liver disease: Beneficial effects of supplementation with microalgae Chlorella vulgaris: A double-blind placebo-controlled randomized clinical trial. Clin Nutr. 2017 Aug;36(4):1001-1006. doi: 10.1016/j.clnu.2016.07.004. Epub 2016 Jul 19.
  28. Mameghani ME, Aliashrafi S, Javadzadeh Y. The Effect of Chlorella vulgaris Supplementation on Liver En-zymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease. Health Promot Perspect. 2014 Jul 12;4(1):107-15. doi: 10.5681/hpp.2014.014. eCollection 2014.
  29. Panahi Y, Ghamarchehreh ME, Beiraghdar F. Investigation of the effects of Chlorella vulgaris supplementation in patients with non-alcoholic fatty liver disease: a randomized clinical trial. Hepatogastroenterology. 2012 Oct;59(119):2099-2103. doi: 10.5754/hge10860.
  30. Gulati S, Wells JM. Bringing Stability to the Chronic Obstructive Pulmonary Disease Patient: Clinical and Pharmacological Considerations for Frequent Exacerbators. Drugs. 2017 Apr;77(6):651-670. doi: 10.1007/s40265-017-0713-5.
  31. Qu J, Do DC, Zhou Y. Oxidized CaMKII promotes asthma through the activation of mast cells. JCI Insight. 2017 Jan 12;2(1):e90139. doi: 10.1172/jci.insight.90139.
  32. Boer A, Worp WR, Hageman GJ. The effect of dietary components on inflammatory lung diseases – a literature review. Int J Food Sci Nutr. 2017 Nov;68(7):771-787. doi: 10.1080/09637486.2017.1288199. Epub 2017 Feb 14.
  33. Umemoto S, Otsuki T. Chlorella-derived multicomponent supplementation increases aerobic endurance capacity in young individuals. J Clin Biochem Nutr. 2014 Sep;55(2):143-6. doi: 10.3164/jcbn.14-58. Epub 2014 Jul 31.
  34. Gille A, Trautmann A, Posten C. Bioaccessibility of carotenoids from Chlorella vulgaris and Chlamydomonas reinhardtii. Int J Food Sci Nutr. 2015 Aug;67(5):507-13. doi: 10.1080/09637486.2016.1181158. Epub 2016 May 5.
  35. Cai X, Huang Q, Wang S. Isolation of a novel lutein-protein complex from Chlorella vulgaris and its functional properties. Food Funct. 2015 Jun;6(6):1893-9. doi: 10.1039/c4fo01096e.
  36. Miyazawa T, Nakagawa K, Kimura F. Chlorella is an effective dietary source of lutein for human erythrocytes. J Oleo Sci. 2013;62(10):773-9. doi: 10.5650/jos.62.773.
  37. Azocar J, Diaz A. Efficacy and safety of Chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol. 2013 Feb 21; 19(7): 1085-1090. Published online 2013 Feb 21. doi: 10.3748/wjg.v19.i7.1085
  38. Canning S, Waterman M, Dye L. Dietary supplements and herbal remedies for premenstrual syndrome (PMS): a systematic research review of the evidence for their efficacy. Review published: 2006.
  39. Bedoya PO, Manson JE, Hankinson SE. Dietary B vitamin intake and incident premenstrual syndrome. Am J Clin Nutr. 2011 May; 93(5): 1080-1086. Published online 2011 Feb 23. doi: 10.3945/ajcn.110.009530
  40. Mason R. Chlorella and Spirulina: Green Supplements for Balancing the Body. Alternative and Complementary TherapiesVol. 7, No. 3. Published Online:5 Jul 2004. https://doi.org/10.1089/107628001300303691
  41. Simmons DB, Hayward AR, Hutchinson TC. Identification and quantification of glutathione and phytochelatins from Chlorella vulgaris by RP-HPLC ESI-MS/MS and oxygen-free extraction. Anal Bioanal Chem (2009) 395:809-817 DOI 10.1007/s00216-009-3016
  42. Schmidt R, Berssenbrügge G, EllroƩ T, Gahmann, H.; Hirschfelder, G.; Krüger, J.; Schebek, L.; Wippermann, P.: Ernährung der ZukunŌ , Nestle ZukunŌ sstudie, 2015, hƩ p://www.nestle.de/zukunŌ sstudie, Zugriff : 15 .12.2015
  43. Egner PA, Wang JB, Zhu YR. Chlorophyllin intervention on reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14601-6.
  44. Breinholt V, Hendricks J, Pereira C. Dietary chlorophyllin is a potent inhibitor of aflatoxin B1 hepatocarcinogenesis in rainbow trout. Cancer Res. 1995 Jan 1;55(1):57-62.
  45. Kensler TW, Egner PA, Wang JB. Chemoprevention of hepatocellular carcinoma in afl atoxin endemic areas. Gastroenterology. 2004 Nov;127 (5 Suppl 1):S310-8.
  46. Tang G, Suter PM. Vitamin A, Nutrition, and Health Values of Algae: Spirulina, Chlorella, and Dunaliella. Journal of Pharmacy and Nutrition Sciences. 2011; 1 (2): 111-119
  47. Panahi Y, Mostafazadeh B, Abrishami A. Investigation of the eff ects of Chlorella vulgaris supplementation on the modulation of oxidative stress in apparently healthy smokers. Clin Lab. 2013;59(5-6):579-87.
  48. Blas-Valdivia V, Rocío Ortiz-Butron, Marisol Pineda-Reynoso, Edgar Cano-Europa. Chlorella vulgaris administration prevents HgCl2-induced oxidative stress and cellular damage in the kidney. J Appl Phycol (2011) 23: 53-58.
  49. Aizzat O, Yap SW, Sopiah H, Madiha MM, Hazreen M, Shailah A, Wan Junizam WY, Nur Syaidah A, Srijit Das, Musalmah M, Yasmin Anum MY. Modulation of oxidative stress by Chlorella vulgaris in streptozotocin (STZ) induced diabetic Sprague-Dawley rats. Advances in Medical Sciences. 2010; 55(2): 281-288.
  50. Na Hee Ryu, Yeni Lim, Ji Eeun Park, Joohee Kim, Ji Yeon Kim, Sung Won Kwon, Oran Kwon. Impact of daily Chlorella consumption on serum lipid and carotenoid profiles in mildly hypercholesterolemic adults: a double-blinded, randomized, placebo-controlled study. Nutrition Journal. 2014; 13: 57.
  51. Jung Hyun Kwak, Seung Han Baek, Yongje Woo, Jae Kab Han, Byung Gon Kim, Oh Yoen Kim and Jong Ho Lee. Beneficial immunostimulatory effect of short-term Chlorella supplementation: enhancement of Natural Killer cell activity and early inflammatory response (Randomized, double-blinded, placebo-controlled trial). Nutrition Journal. 2012; 11: 53-61.
  52. Seyed Mohammad Nabavi and Ana Sanches Silva. Part III: Plant and Algae Extracts 3.10 Chlorella In: JoanaSilva, CelsoAlves, SusetePinteus, JoãoReboleira, RuiPedrosa, SusanaBernardino. Nonvitamin and Nonmineral Nutritional Supplements. 1st edition. Academic Press. 2019; 187- 193.
  53. Paul Tse. The Detoxification, Immunostimulation And Healing Property Of Chlorella. World Convention of Traditional Medicine & Acupuncture; March 18 and 19, 2000; Singapore
  54. Steinberg KH, Ecke M, Ullmann J. Chlorella – neue Wege der Prävention und Heilung, OM & Ernährung,2009; 127: 1-12.
  55. Ecke M and Ullmann J. Der Einsatz von Chlorella vulgaris Mikroalgen zur Schwermetallausleitung aus naturwissenschaŌ licher Sicht. OM & Ernährun.2009; 129: F10-14.
  56. K Morita, M Ogata, and T Hasegawa. Chlorophyll derived from Chlorella inhibits dioxin absorption from the gastrointestinal tract and accelerates dioxin excretion in rats. Environ Health Perspect. 2001 Mar; 109(3): 289- 294.
  57. K. Suresh Kumar, Hans-Uwe Dahms, Eun-Ji Won, Jae-Seong Lee, KyungHoon Shin. Review: Microalgae – A promising tool for heavy metal remediation. Ecotoxicology and Environmental Safety, March 2015; 113:329- 352.
  58. Anthony G. Day, David Brinkmann, ScoƩ Franklin, Karen Espina, George Rudenko, Ashley Roberts, Kerry S. Howse. Safety evaluation of a highlipid algal biomass from Chlorella protothecoides. Regulatory Toxicology and Pharmacology. November 2, 2009; 55 (2):166-180.
  59. Giulia Graziani, Simona Schiavo,Maria Adalgisa Nicolai,Silvia Buono, Vincenzo Fogliano,Gabriele Pintoac, Antonino Pollio. Microalgae as human food: chemical and nutritional characteristics of the thermo-acidophilic microalga Galdieria sulphurari. Food Funct. 2013; 4: 144-152.
  60. Nakano S, Noguchi T, Takekoshi H, Suzuki G, Nakano M. Maternal-fetal distribution and transfer of dioxins in pregnant women in Japan, and aƩ empts to reduce maternal transfer with Chlorella (Chlorella pyrenoidosa) supplements. Chemosphere. 2005 Dec;61(9):1244-55.
  61. Nakano S, Takekoshi H, Nakano M. Chlorella (Chlorella pyrenoidosa) supplementation decreases dioxin and increases immunoglobulin a concentrations in breast milk. J Med Food. 2007 Mar;10(1):134-42.
  62. Alice N. Lee, Victoria P. Werth. Activation of Autoimmunity Following Use of Immunostimulatory Herbal Supplements. Arch Dermatol. 2004 Jun;140(6):723-7.
  63. Jose Azocar, Arley Diaz. Efficacy and safety of Chlorella supplementation in adults with chronic hepatitis C virus infection. World J Gastroenterol 2013 February 21; 19(7): 1085-1090.
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